Tetraspanins at a glance

被引：375

作者：

Charrin, Stephanie ^{[1
,2
]}

Jouannet, Stephanie ^{[1
,2
]}

Boucheix, Claude ^{[1
,2
]}

Rubinstein, Eric ^{[1
,2
]}

机构：

[1] INSERM, U1004, F-94807 Villejuif, France

[2] Univ Paris Sud, Inst Andre Lwoff, F-94807 Villejuif, France

来源：

JOURNAL OF CELL SCIENCE | 2014年 / 127卷 / 17期

关键词：

Tetraspanin; Integrin; Membrane compartmentalization; RETINAL VASCULAR DEVELOPMENT; ENRICHED MICRODOMAINS; EXTRACELLULAR DOMAIN; INTEGRIN ALPHA-3-BETA-1; CELL-INTERACTIONS; STRUCTURAL BASIS; PROSTATE-CANCER; PLASMA-MEMBRANE; GROWTH-FACTOR; CD81; PARTNER;

D O I：

10.1242/jcs.154906

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Tetraspanins are a family of proteins with four transmembrane domains that play a role in many aspects of cell biology and physiology; they are also used by several pathogens for infection and regulate cancer progression. Many tetraspanins associate specifically and directly with a limited number of proteins, and also with other tetraspanins, thereby generating a hierarchical network of interactions. Through these interactions, tetraspanins are believed to have a role in cell and membrane compartmentalization. In this Cell Science at a Glance article and the accompanying poster, we describe the basic principles underlying tetraspanin-based assemblies and highlight examples of how tetraspanins regulate the trafficking and function of their partner proteins that are required for the normal development and function of several organs, including, in humans, the eye, the kidney and the immune system.

引用

页码：3641 / 3648

页数：8

共 130 条

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