Towards the rehabilitation of the Mathews' 'dry' hydrolysis reaction using microwave technology

被引：14

作者：

Chemat, F ^{[1
]}

机构：

[1] Univ Reunion, Fac Sci & Technol, Lab Chim Subst Nat & Sci Aliments, 15 Ave Rene Cassin,BP 7151, F-97715 St Denis Messageries 9, Reunion, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 32期

关键词：

hydrolysis; microwave; nitrile; amid; carboxylic acid;

D O I：

10.1016/S0040-4039(02)01127-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mathews' reaction is a one-pot preparation of carboxylic acids from their corresponding nitriles or amides by a 'dry' hydrolysis with phthalic acid or anhydride in the absence of water and solvent. Excellent isolated yields and selectivity (Lip to 99%) were attained within short reaction times (typically, 30 minutes) when the reaction was performed under microwave heating. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：5555 / 5557

页数：3

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