Enhancement of reaction rates by segmented fluid flow in capillary scale reactors

被引:115
作者
Ahmed, Batoul
Barrow, David [1 ]
Wirth, Thomas
机构
[1] Cardiff Univ, Cardiff Sch Engn, Lab Appl Microsyst, Cardiff CF24 3AA, Wales
[2] Cardiff Univ, Cardiff Sch Chem, Cardiff CF10 3AT, Wales
关键词
biphasic reactions; Heck reaction; hydrolysis; microreactors; segmented flow;
D O I
10.1002/adsc.200505480
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
For a simple biphasic hydrolysis, we show that the application of various reaction conditions in microreactors using segmented flow can dramatically increase the reaction rate. A tandem diazotation/Heck reaction served as an example that even homogeneous reactions can be accelerated by segmentation in microreactors.
引用
收藏
页码:1043 / 1048
页数:6
相关论文
共 41 条
  • [31] Two-phase flow in microchannels
    Serizawa, A
    Feng, ZP
    Kawara, Z
    [J]. EXPERIMENTAL THERMAL AND FLUID SCIENCE, 2002, 26 (6-7) : 703 - 714
  • [32] Effect of channel structure on microchannel emulsification
    Sugiura, S
    Nakajima, M
    Seki, M
    [J]. LANGMUIR, 2002, 18 (15) : 5708 - 5712
  • [33] Dynamic pattern formation in a vesicle-generating microfluidic device
    Thorsen, T
    Roberts, RW
    Arnold, FH
    Quake, SR
    [J]. PHYSICAL REVIEW LETTERS, 2001, 86 (18) : 4163 - 4166
  • [34] Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers
    Tice, JD
    Song, H
    Lyon, AD
    Ismagilov, RF
    [J]. LANGMUIR, 2003, 19 (22) : 9127 - 9133
  • [35] Phase-transfer alkylation reactions using microreactors
    Ueno, M
    Hisamoto, H
    Kitamori, T
    Kobayashi, S
    [J]. CHEMICAL COMMUNICATIONS, 2003, (08) : 936 - 937
  • [36] The application of microreactors for small scale organic synthesis
    Watts, P
    Haswell, SJ
    [J]. CHEMICAL ENGINEERING & TECHNOLOGY, 2005, 28 (03) : 290 - 301
  • [37] Yen BK, 2005, ANGEW CHEM, V117, P5583, DOI DOI 10.1002/ange.200500792
  • [38] A microfabricated gas-liquid segmented flow reactor for high-temperature synthesis:: The case of CdSe quantum dots
    Yen, BKH
    Günther, A
    Schmidt, MA
    Jensen, KF
    Bawendi, MG
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (34) : 5447 - 5451
  • [39] Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets
    Zheng, B
    Roach, LS
    Ismagilov, RF
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (37) : 11170 - 11171
  • [40] A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/gas flow
    Zheng, B
    Ismagilov, RF
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (17) : 2520 - 2523