Centrosomes and tumour suppressors

被引：28

作者：

Fisk, HA ^{[1
]}

Mattison, CP ^{[1
]}

Winey, M ^{[1
]}

机构：

[1] Univ Colorado, Boulder, CO 80309 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(02)00385-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Centrosomes are microtubule organising centres that act as spindle poles during mitosis. Recent work implicates centrosomes in many other processes, and shows that centrosome defects can cause genetic instability. Many regulators of mammalian centrosome function were predicted from studies of model systems. Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability.

引用

页码：700 / 705

页数：6

共 57 条

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