A novel extended-spectrum TEM-type β-lactamase, TEM-138, from Salmonella enterica serovar infantis

被引：16

作者：

Chouchani, Chedly

Berlemont, Renaud

Masmoudi, Afef

Galleni, Moreno

Frere, Jean-Marie

Belhadj, Omrane

Ben-Mahrez, Kamel

机构：

[1] Fac Sci Tunis, Lab Biochim & Biotechnol, Tunis 2092, Tunisia

[2] Univ Liege, Lab Macromol Biol, Ctr Ingn Prot, B-4000 Sart Tilman Par Liege, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 09期

关键词：

D O I：

10.1128/AAC.00388-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel natural TEM beta-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N1751, and G238S. The bla(TEM-138) gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.

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页码：3183 / 3185

页数：3

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