Receptors for bitter and sweet taste

被引：101

作者：

Montmayeur, JP

Matsunami, H

机构：

[1] Ctr Natl Rech Sci, Ctr Europeen Sci Gout, F-21000 Dijon, France

[2] Duke Univ, Dept Mol Genet & Microbiol, Ctr Med, Durham, NC 27710 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0959-4388(02)00345-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The identification of two families of receptors, T1Rs and T2Rs, for sweet and bitter taste stimuli has opened the door to understanding some of the basic mechanisms underlying taste transduction in mammals. Studies of the functions of these receptors and their patterns of expression provide important information regarding the detection of structurally diverse taste compounds and the manner in which different taste qualities are encoded in the mouth,

引用

收藏

页码：366 / 371

页数：6

相关论文

共 43 条

[1] A novel family of mammalian taste receptors [J].

Adler, E ;

Hoon, MA ;

Mueller, KL ;

Chandrashekar, J ;

Ryba, NJP ;

Zuker, CS .

CELL, 2000, 100 (06) :693-702

[2] Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function [J].

Angers, S ;

Salahpour, A ;

Bouvier, M .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2002, 42 :409-435

[3] Sucrose consumption in mice: major influence of two genetic loci affecting peripheral sensory responses [J].

Bachmanov, AA ;

Reed, DR ;

Ninomiya, Y ;

Inoue, M ;

Tordoff, MG ;

Price, RA ;

Beauchamp, GK .

MAMMALIAN GENOME, 1997, 8 (08) :545-548

[4] Positional cloning of the mouse saccharin preference (Sac) locus [J].

Bachmanov, AA ;

Li, X ;

Reed, DR ;

Ohmen, JD ;

Li, SR ;

Chen, ZY ;

Tordoff, MG ;

de Jong, PJ ;

Wu, CY ;

West, DB ;

Chatterjee, A ;

Ross, DA ;

Beauchamp, GK .

CHEMICAL SENSES, 2001, 26 (07) :925-933

[5] Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat [J].

Bernhardt, SJ ;

Naim, M ;

Zehavi, U ;

Lindemann, B .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 490 (02) :325-336

[6] Taste receptor cells that discriminate between bitter stimuli [J].

Caicedo, A ;

Roper, SD .

SCIENCE, 2001, 291 (5508) :1557-1560

[7] CHROMOSOME MAPPING OF SOA, A GENE INFLUENCING GUSTATORY SENSITIVITY TO SUCROSE OCTAACETATE IN MICE [J].

CAPELESS, CG ;

WHITNEY, G ;

AZEN, EA .

BEHAVIOR GENETICS, 1992, 22 (06) :655-663

[8] T2Rs function as bitter taste receptors [J].

Chandrashekar, J ;

Mueller, KL ;

Hoon, MA ;

Adler, E ;

Feng, LX ;

Guo, W ;

Zuker, CS ;

Ryba, NJP .

CELL, 2000, 100 (06) :703-711

[9] A metabotropic glutamate receptor variant functions as a taste receptor [J].

Chaudhari, N ;

Landin, MA ;

Roper, SD .

NATURE NEUROSCIENCE, 2000, 3 (02) :113-119

[10]

Chaudhari N, 1996, J NEUROSCI, V16, P3817

← 1 2 3 4 5 →