The case of the unreliable SNP: Recurrent back-mutation of Y-chromosomal marker P25 through gene conversion

被引：31

作者：

Adams, Susan M. ^{[1
]}

King, Turi E. ^{[1
]}

Bosch, Elena ^{[1
]}

Jobling, Mark A. ^{[1
]}

机构：

[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

来源：

FORENSIC SCIENCE INTERNATIONAL | 2006年 / 159卷 / 01期

基金：

英国惠康基金;

关键词：

Y-chromosome; paralog; PSV; SNP; gene conversion; phylogeny;

D O I：

10.1016/j.forsciint.2005.06.003

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The Y-chromosomal binary marker P25 is a paralogous sequence variant, rather than a SNP: three copies of the P25 sequence lie within the giant palindromic repeats on Yq, and one copy has undergone a C to A transversion to define haplogroup R1b (designated C/C/A). Since gene conversion is known to be active in the palindromic repeats, we reasoned that P25 might be liable to back-mutation by gene conversion, yielding the ancestral state C/C/C. Through analysis of a set of binary markers in Y-chromosomes in two large samples from Great Britain and the Iberian Peninsula we show that such conversion events have occurred at least twice, and provide preliminary evidence that the reverse conversion event (yielding C/A/A) has also occurred. Because of its inherent instability, we suggest that P25 be used with caution in forensic studies, and perhaps replaced with the more reliable binary marker M269. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：14 / 20

页数：7

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