Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression

被引：472

作者：

Ren, Guangwen ^{[2
]}

Su, Juanjuan ^{[1
,3
]}

Zhang, Liying ^{[2
]}

Zhao, Xin ^{[2
]}

Ling, Weifang ^{[2
]}

L'Huillie, Andrew ^{[2
]}

Zhang, Jimin ^{[2
]}

Lu, Yongqing ^{[1
,3
]}

Roberts, Arthur I. ^{[2
]}

Ji, Weizhi ^{[3
]}

Zhang, Huatang ^{[3
]}

Rabson, Arnold B. ^{[2
,4
]}

Shi, Yufang ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci, Inst Hlth Sci, Chinese Acad Sci,Key Lab Stem Cell Biol,Sch Med, Shanghai 200025, Peoples R China

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet Microbiol & Immunol, Piscataway, NJ 08854 USA

[3] Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Kunming, Yunnan, Peoples R China

[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ USA

来源：

STEM CELLS | 2009年 / 27卷 / 08期

基金：

美国国家卫生研究院; 美国国家航空航天局;

关键词：

Mesenchymal stem cells; Immunosuppression; Indoleamine 2,3-dioxygenase; Nitric oxide; Chemokine; NITRIC-OXIDE SYNTHASE; T-LYMPHOCYTE PROLIFERATION; VERSUS-HOST-DISEASE; INDOLEAMINE 2,3-DIOXYGENASE; DENDRITIC CELLS; IFN-GAMMA; TRYPTOPHAN DEGRADATION; INTERFERON-GAMMA; MESSENGER-RNA; NO NO;

D O I：

10.1002/stem.118

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Bone marrow-derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial. As we show here, the mechanism of MSC-mediated immunosuppression varies among different species. Immunosuppression by human-or monkey-derived MSCs is mediated by indoleamine 2,3-dioxygenase (IDO), whereas mouse MSCs utilize nitric oxide, under the same culture conditions. When the expression of IDO and inducible nitric oxide synthase (iNOS) were examined in human and mouse MSCs after stimulation with their respective inflammatory cytokines, we found that human MSCs expressed extremely high levels of IDO, and very low levels of iNOS, whereas mouse MSCs expressed abundant iNOS and very little IDO. Immunosuppression by human MSCs was not intrinsic, but was induced by inflammatory cytokines and was chemokine-dependent, as it is in mouse. These findings provide critical information about the immunosuppression of MSCs and for better application of MSCs in treating immune disorders. STEM CELLS 2009;27:1954-1962

引用

页码：1954 / 1962

页数：9

共 43 条

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