Coating of electrospun poly(lactic-co-glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model

被引：35

作者：

Adegani, Fatemeh Jamshidi ^{[1
]}

Langroudi, Lida ^{[1
]}

Ardeshirylajimi, Abdolreza ^{[2
]}

Dinarvand, Peyman ^{[2
]}

Dodel, Masumeh ^{[3
,4
]}

Doostmohammadi, Ali ^{[5
]}

Rahimian, Ali ^{[1
]}

Zohrabi, Parastoo ^{[6
]}

Seyedjafari, Ehsan ^{[7
]}

Soleimani, Masoud ^{[8
]}

机构：

[1] Stem Cell Technol Res Ctr, Dept Mol Biol & Genet Engn, Tehran, Iran

[2] Stem Cell Technol Res Ctr, Dept Stem Cell Biol, Tehran, Iran

[3] Stem Cell Technol Res Ctr, Dept Nanotechnol & Tissue Engn, Tehran, Iran

[4] Amirkabir Univ Technol, Dept Text Engn, Tehran, Iran

[5] Isfahan Univ Technol, Dept Mat Engn, Biomat Grp, Esfahan, Iran

[6] Univ Tehran Med Sci, Dept Med Sci, Tehran, Iran

[7] Univ Tehran, Coll Sci, Dept Biotechnol, Tehran, Iran

[8] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol, Tehran, Iran

来源：

CELL BIOLOGY INTERNATIONAL | 2014年 / 38卷 / 11期

关键词：

bone; calvarial defects; electrospinning; tissue engineering; willemite; OF-THE-ART; STEM-CELLS; CALCIUM-PHOSPHATE; IN-VIVO; TRICALCIUM PHOSPHATE; COMPOSITE SCAFFOLDS; ENDOTHELIAL-CELLS; TISSUE; DESIGN; POLY(L-LACTIDE);

D O I：

10.1002/cbin.10318

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

We have investigated the combination effects of bioceramics and poly(lactide-co-glycolide) (PLGA) on bone reconstruction in calvarial critical size defects using a rat model. Willemite (Zn2SiO4) ceramics were prepared and coated on the surface of electrospun fabricated scaffolds. After scaffolds and nanoparticles characterization, osteoconductivity of the construct was analyzed using digital mammography, multislice spiral-computed tomography (MSCT) imaging, and histological analysis. Eight weeks after implantation, no sign of inflammation was observed at the site of the osseous defect. The results showed that the ceramics supported bone regeneration and highest bone reconstruction were observed in willemite-coated PLGA. This suggests that electrospun PLGA nanofibers coated with BG are potential candidate implants for bone tissue engineering applications.

引用

页码：1271 / 1279

页数：9

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