Regulation of energy metabolism by the skeleton: Osteocalcin and beyond

被引：141

作者：

Ferron, Mathieu ^{[1
,2
]}

Lacombe, Julie ^{[1
]}

机构：

[1] Inst Rech Clin Montreal, Lab Physiol Integrat & Mol, Montreal, PQ H2W 1R7, Canada

[2] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 561卷

基金：

加拿大健康研究院;

关键词：

Osteocalcin; Glucose metabolism; Energy metabolism; Osteoblast; Osteoclast; Insulin; PROTEIN-TYROSINE-PHOSPHATASE; TYPE-2; DIABETES-MELLITUS; POLYCYSTIC-OVARY-SYNDROME; FATTY LIVER-DISEASE; SERUM UNDERCARBOXYLATED OSTEOCALCIN; PANCREATIC BETA-CELL; DIET-INDUCED OBESITY; ABDOMINAL AORTIC CALCIFICATION; ENDOPLASMIC-RETICULUM STRESS; EARLY POSTMENOPAUSAL WOMEN;

D O I：

10.1016/j.abb.2014.05.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The skeleton has recently emerged as an endocrine organ implicated in the regulation of glucose and energy metabolism. This function of bone is mediated, at least in part, by osteocalcin, an osteoblast-derived protein acting as a hormone stimulating insulin sensitivity, insulin secretion and energy expenditure. Osteocalcin secretion and bioactivity is in turn regulated by several hormonal cues including insulin, leptin, the sympathetic nervous system and glucocorticoids. Recent findings support the notion that osteocalcin functions and regulations are conserved between mice and humans. Moreover, studies in mice suggest that osteocalcin could represent a viable therapeutic approach for the treatment of obesity and insulin resistance. In this review, we summarize the current knowledge on osteocalcin functions, its various modes of action and the mechanisms implicated in the control of this hormone. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：137 / 146

页数：10

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