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Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

被引：445
作者：
Slee, EA
Zhu, HJ
Chow, SC
MacFarlane, M
Nicholson, DW
Cohen, GM
机构：
[1] UNIV LEICESTER, MRC, TOXICOL UNIT, LEICESTER LE1 9HN, LEICS, ENGLAND
[2] MERCK FROSST CTR THERAPEUT RES, DEPT BIOCHEM & MOLEC BIOL, POINTE CLAIRE, PQ H9R 4P8, CANADA
[3] UNIV LEICESTER, CTR MECHANISMS HUMAN TOX, LEICESTER LE1 9HN, LEICS, ENGLAND
来源：
BIOCHEMICAL JOURNAL | 1996年 / 315卷
关键词：
D O I：
10.1042/bj3150021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin-1 beta converting enzyme (ICE)-like proteases, which are synthesized as inactive precursors, play a key role in the induction of apoptosis. We now demonstrate that benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK), an ICE-like protease inhibitor, inhibits apoptosis by preventing the processing of CPP32 to its active form. These results suggest that novel inhibitors of apoptosis can be developed which prevent processing of proforms of ICE-like proteases.
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页码：21 / 24
页数：4
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