CGRP receptors in the control of pain and inflammation

被引：149

作者：

Benemei, Silvia ^{[1
]}

Nicoletti, Paola ^{[1
]}

Capone, Jay G. ^{[2
]}

Geppetti, Pierangelo ^{[1
,2
]}

机构：

[1] Univ Florence, Ctr Study Headache, Florence, Italy

[2] S Anna Univ Hosp, Headache Ctr, Ferrara, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 01期

关键词：

GENE-RELATED-PEPTIDE; ISOLATED RAT HEARTS; TRIGEMINOVASCULAR SYSTEM; EXTRACEREBRAL CIRCULATION; NEUROPEPTIDE CHANGES; MYOCARDIAL-ISCHEMIA; CAPSAICIN RECEPTOR; MIGRAINE HEADACHE; BLOOD-VESSELS; SUBSTANCE-P;

D O I：

10.1016/j.coph.2008.12.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain transmission and inflammation and for these reasons to the mechanism of migraine. CGRP is, in fact, expressed in and released from a subset of polymodal primary sensory neurons of the trigeminal ganglion. Release of CGRP in the dorsal spinal cord has been associated to nociceptive transmission, and release from perivascular nerve endings causes neurogenic vasodilatation. CGRP levels increase in the cranial circulation during migraine attacks, and GRP injection in migraineurs results in migraine-like attacks. Most importantly, two chemically unrelated CGRP-receptor antagonists, the parenteral agent, olcegepant, and the orally available telcagepant demonstrated efficacy in the treatment of migraine attacks, thus supporting CGRP as an important mediator in migraine.

引用

收藏

页码：9 / 14

页数：6

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