Self-assembling polymer-peptide conjugates: Nanostructural tailoring

被引：113

作者：

Collier, JH ^{[1
]}

Messersmith, PB ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

来源：

ADVANCED MATERIALS | 2004年 / 16卷 / 11期

关键词：

D O I：

10.1002/adma.200306379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modulation of nanoscale assembly of febrils by incorporating polyethylene glycol into the backbone of self assembling β-sheets was analyzed. Insertion of nonpeptide random-coil-forming polymers within the peptide backbone modulated βsheet fibril dimensions. It was found that Q11-PEG produced different nanostructures from unmodified Q11. Alternative Methods for producing β-sheet peptide PEG copolymers broadened the synthetic possibilities for producing the structures.

引用

页码：907 / 910

页数：4

共 21 条

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