Genetics for targeting disease prevention: diabetes

被引:8
作者
Newell, AM [1 ]
机构
[1] Oregon State Genet Program, Oregon Dept Human Serv, Portland, OR 97232 USA
来源
PRIMARY CARE | 2004年 / 31卷 / 03期
关键词
D O I
10.1016/j.pop.2004.04.002
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
This article provides an overview of current thinking regarding genetics and diabetes (type 1, type 2, and gestational diabetes mellitus), including a selective look at a few implicated gene variants. This article explores how this information might be applied in current and future clinical practice to (1) predict who is at risk for diabetes and its complications, (2) identify and intervene to prevent or delay the development of diabetes in persons at risk, (3) identify patients with diabetes in an early stage and intervene to prevent later complications, and (4) individualize therapy for patients with diabetes to improve outcomes. The article concludes with some general thoughts about genetics and diabetes prevention in the future.
引用
收藏
页码:743 / +
页数:25
相关论文
共 125 条
[11]   APOE genotype is a risk factor for neuropathy severity in diabetic patients [J].
Bedlack, RS ;
Edelman, D ;
Gibbs, JW ;
Kelling, D ;
Strittmatter, W ;
Saunders, AM ;
Morgenlander, J .
NEUROLOGY, 2003, 60 (06) :1022-1024
[12]   Estimated number of adults with prediabetes in the US in 2000 - Opportunities for prevention [J].
Benjamin, SM ;
Valdez, R ;
Geiss, LS ;
Rolka, DB ;
Narayan, KMV .
DIABETES CARE, 2003, 26 (03) :645-649
[13]   Human type 1 diabetes and the insulin gene: Principles of mapping polygenes [J].
Bennett, ST ;
Todd, JA .
ANNUAL REVIEW OF GENETICS, 1996, 30 :343-370
[14]   Screening for gestational diabetes mellitus: Recommendations and rationale [J].
Berg, AO ;
Allan, JD ;
Frame, P ;
Homer, CJ ;
Johnson, MS ;
Klein, JD ;
Lieu, TA ;
Orleans, CT ;
Peipert, JF ;
Pender, NJ ;
Siu, AL ;
Teulsch, SM ;
Westhoff, C ;
Woolf, SH .
OBSTETRICS AND GYNECOLOGY, 2003, 101 (02) :393-395
[15]  
Berzina L, 2002, ANN NY ACAD SCI, V958, P312
[16]   Diabetic retinopathy and HLA antigens in type 2 diabetes mellitus [J].
Birinci, A ;
Birinci, H ;
Abidinoglu, R ;
Durupinar, B ;
Öge, I .
EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2002, 12 (02) :89-93
[17]   Type 2 diabetes and maternal family history - An impact beyond slow glucose removal rate and fasting hyperglycemia in low-risk individuals? Results from 22.5 years of follow-up of healthy nondiabetic men [J].
Bjornholt, JV ;
Erikssen, G ;
Liestol, K ;
Jervell, J ;
Thaulow, E ;
Erikssen, J .
DIABETES CARE, 2000, 23 (09) :1255-1259
[18]  
Boulot P, 2003, DIABETES CARE, V26, P2990
[19]   Genetics of diabetes complications. [J].
Bowden D.W. .
Current Diabetes Reports, 2002, 2 (2) :191-200
[20]   Projection of diabetes burden through 2050 - Impact of changing demography and disease prevalence in the US [J].
Boyle, JP ;
Honeycutt, AA ;
Narayan, KMV ;
Hoerger, TJ ;
Geiss, LS ;
Chen, H ;
Thompson, TJ .
DIABETES CARE, 2001, 24 (11) :1936-1940