A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility

被引：17

作者：

Bonetti, Alessandro ^{[1
,2
]}

Koivisto, Keijo ^{[3
]}

Pirttila, Tuula ^{[4
,5
]}

Elovaara, Irina ^{[6
,7
]}

Reunanen, Mauri ^{[8
,9
]}

Laaksonen, Mikko ^{[10
,11
,12
]}

Ruutiainen, Juhani ^{[13
]}

Peltonen, Leena ^{[14
,15
]}

Rantamaki, Terhi ^{[1
,2
]}

Tienari, Pentti J. ^{[1
,2
]}

机构：

[1] Univ Helsinki, Mol Neurosci Programme, Helsinki 00029, Finland

[2] Univ Helsinki, Cent Hosp, FIN-00290 Helsinki, Finland

[3] Cent Hosp Seinajoki, Seinajoki, Finland

[4] Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland

[5] Kuopio Univ Hosp, SF-70210 Kuopio, Finland

[6] Univ Tampere, Dept Neurol, FIN-33101 Tampere, Finland

[7] Tampere Univ Hosp, Tampere, Finland

[8] Univ Oulu, Dept Neurol, Oulu, Finland

[9] Oulu Univ Hosp, Oulu, Finland

[10] Turku Immunol Ctr, Turku, Finland

[11] Univ Turku, Dept Virol, Turku, Finland

[12] Univ Turku, Dept Neurol, Turku, Finland

[13] Masku Neurol Rehabil Ctr, Masku, Finland

[14] Univ Helsinki, Natl Publ Hlth Inst, Helsinki 00029, Finland

[15] Wellcome Trust Sanger Inst, Hinxton, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 208卷 / 1-2期

基金：

芬兰科学院;

关键词：

Multiple sclerosis; APOE; HLA-DR15; ILT6; LINKAGE DISEQUILIBRIUM; GENOME SCREEN; ITALIAN FAMILIES; ASSOCIATION; GENE; REGION; LOCI; FINLAND; POPULATIONS; COMPLEX;

D O I：

10.1016/j.jneuroim.2009.01.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A possible role of allelic variation on chromosome 19q13 in multiple sclerosis (MS) susceptibility has been suggested. We tested association of sixteen 19q13 markers with MS in 459 families. Nominally significant associations were tested in an independent set of 323 families as well as in the pooled set of 782 families. We were not able to confirm previously suggested associations with APOE, GIPR, ZNF45, ILT6 and D19S535. In the screening dataset nominally significant associations were found with D19S867 and with APOE haplotype (p = 0.007 in both), but these were not replicated in the independent dataset nor in the pooled analysis of 757 families. Thus, we were not able to detect any statistically significant allelic associations. Re-sequencing based approaches may be required for elucidating the role chromosome 19q13 with MS. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：119 / 124

页数：6

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