Activity of GAR-936 and other antimicrobial agents against North American isolates of Staphylococcus aureus

被引:21
作者
Low, DE
Kreiswirth, BN
Weiss, K
Willey, BM
机构
[1] Mt Sinai Hosp, Dept Microbiol, Toronto Med Labs, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[3] Publ Hlth Res Inst, New York, NY USA
[4] Univ Montreal, Hop Maison Neuve Rosemont, Montreal, PQ, Canada
关键词
methicillin-resistant Staphylococcus aureus; GAR-936; linezolid; quinupristin/dalfopristin;
D O I
10.1016/S0924-8579(02)00132-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The comparative in vitro activity of GAR-936 and 12 other drugs against 602 North American isolates of methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus was determined. The GAR-936 MICs ranged from 0.06 to 1.0 mg/l. The MIC(50)s and MIC(90)s were 0.12 and 0.25 mg/l for MSSA and 0.25 and 0.5 mg/l for MRSA. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:220 / 222
页数:3
相关论文
共 14 条
[1]  
[Anonymous], PERF STAND ANT SUSC
[2]   In vitro activities of the glycylcycline GAR-936 against gram-positive bacteria [J].
Boucher, HW ;
Wennersten, CB ;
Eliopoulos, GM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) :2225-2229
[3]   GAR-936 (9-t-butylglycylamido-minocycline) susceptibility test development for streptococci, Haemophilus influenzae and Neisseria gonorrhoeae:: preliminary guidelines and interpretive criteria [J].
Deshpande, LM ;
Gales, AC ;
Jones, RN .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 18 (01) :29-35
[4]  
Edlund C, 2000, CLIN MICROBIOL INFEC, V6, P158
[5]   Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci [J].
Hoellman, DB ;
Pankuch, GA ;
Jacobs, MR ;
Appelbaum, PC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (04) :1085-1088
[6]   Quinupristin/dalfopristin and linezolid: where, when, which and whether to use? [J].
Livermore, DM .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (03) :347-350
[7]   Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis [J].
Murphy, TM ;
Deitz, JM ;
Petersen, PJ ;
Mikels, SM ;
Weiss, WJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :3022-3027
[8]  
National Committee for Clinical Laboratory Standards, 2000, METH DIL ANT SUSC TE
[9]   Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus [J].
O'Neill, AJ ;
Cove, JH ;
Chopra, I .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 47 (05) :647-650
[10]   In vitro activity of GAR-936 against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae [J].
Patel, R ;
Rouse, MS ;
Piper, KE ;
Steckelberg, JM .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2000, 38 (03) :177-179