The stem cell continuum - Considerations on the heterogeneity and plasticity of marrow stem cells

被引：9

作者：

Quesenberry, Peter J. ^{[1
]}

Dooner, G. ^{[1
]}

Dooner, M. ^{[1
]}

Colvin, G. ^{[1
]}

机构：

[1] Ctr Stem Cell Biol, Roger Williams Med Ctr, Res Dept, Providence, RI 02908 USA

来源：

STEM CELL REVIEWS | 2005年 / 1卷 / 01期

关键词：

marrow; stem cell; continuum; hierarchy; cell cycle;

D O I：

10.1385/SCR:1:1:029

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Traditional models of hematopoiesis have been hierarchical. Recent evidence showing that marrow stem cells are a cycling population and that the hematopoietic phenotype of these cells reversibly changes with cycle transit have suggested a continuum model of stem cell regulators. Studies on marrow cell conversion to lung cells have extended this continuum to cycle-related differentiation into nonhernatopoietic stem cells. We postulate that stem cells transiting cell cycle continually change their chromatin structure, thus providing different windows of transcriptional opportunity and a continually changing phenotype. Final outcomes with this continuum model would be determined by the specific chromatin state of the cell and the presence of specific differentiation inducers.

引用

页码：29 / 36

页数：8

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