Regulation and function of selenoproteins in human disease

被引：296

作者：

Bellinger, Frederick P. ^{[1
]}

Raman, Arjun V. ^{[1
]}

Reeves, Mariclair A. ^{[1
]}

Berry, Marla J. ^{[1
]}

机构：

[1] Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA

来源：

BIOCHEMICAL JOURNAL | 2009年 / 422卷

关键词：

cancer; diabetes; Keshan disease; multiminicore disease; neurodegeneration; selenium; selenocysteine; selenoprotein; thyroid hormone; SELENOCYSTEINE INSERTION-SEQUENCE; GLUTATHIONE-PEROXIDASE DEFICIENCY; RECEPTOR-STIMULATED HYPERTROPHY; DIETARY SELENIUM REQUIREMENTS; CORONARY-HEART-DISEASE; MESSENGER-RNA LEVELS; PARKINSONS-DISEASE; SERUM SELENIUM; MYOCARDIAL-INFARCTION; PROMOTER POLYMORPHISM;

D O I：

10.1042/BJ20090219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors; and oil dietary selenium. Although the functions of many selenoproteins; are unknown, several disorders involving changes in selenoprotein structure, activity or expression have been reported. Selenium deficiency and mutations or polymorphisms in selenoprotein genes and synthesis cofactors are implicated in a variety of diseases, including muscle and cardiovascular disorders, immune dysfunction, cancer, neurological disorders and endocrine function. Members of this unusual family of proteins have roles in a variety of cell processes and diseases.

引用

页码：11 / 22

页数：12

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