Microtubule assembly, organization and dynamics in axons and dendrites

被引：799

作者：

Conde, Cecilia ^{[1
]}

Caceres, Alfredo ^{[1
]}

机构：

[1] INIMEC CONICET, Inst Invest Med Mercedes & Martin Ferreyra, Lab Neurobiol Celular & Mol, RA-5016 Cordoba, Argentina

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 05期

关键词：

NEURONAL GROWTH CONE; ALPHA-BETA-TUBULIN; CEREBELLAR MACRONEURONS; HIPPOCAMPAL-NEURONS; NEURITE OUTGROWTH; MEMBRANE EXPANSION; RHO-GTPASES; SAD KINASES; PROTEIN; POLARITY;

D O I：

10.1038/nrn2631

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During the past decade enormous advances have been made in our understanding of the basic molecular machinery that is involved in the development of neuronal polarity. Far from being mere structural elements, microtubules are emerging as key determinants of neuronal polarity. Here we review the current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites. These studies provide new insight into microtubules' function in neuronal development and their potential contribution to plasticity.

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收藏

页码：319 / 332

页数：14

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