Common KIBRA alleles are associated with human memory performance

被引：324

作者：

Papassotiropoulos, Andreas ^{[1
]}

Stephan, Dietrich A.

Huentelman, Matthew J.

Hoerndli, Frederic J.

Craig, David W.

Pearson, John V.

Huynh, Kim-Dung

Brunner, Fabienne

Corneveaux, Jason

Osborne, David

Wollmer, M. Axel

Aerni, Amanda

Coluccia, Daniel

Haenggi, Juergen

Mondadori, Christian R. A.

Buchmann, Andreas

Reiman, Eric M.

Caselli, Richard J.

Henke, Katharina

de Quervain, Dominique J. -F.

机构：

[1] Univ Zurich, Div Psychiat Res, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland

[3] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ 85004 USA

[4] Mayo Clin, Dept Neurol, Scottsdale, AZ 85259 USA

[5] Univ Arizona, Dept Psychiat, Phoenix, AZ 85006 USA

[6] Univ Arizona, Banner Alzheimers Inst, Phoenix, AZ 85006 USA

[7] Mayo Clin, Dept Psychol, Scottsdale, AZ 85259 USA

来源：

SCIENCE | 2006年 / 314卷 / 5798期

关键词：

D O I：

10.1126/science.1129837

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

引用

页码：475 / 478

页数：4

共 28 条

[1] Voxel-based morphometry - The methods [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2000, 11 (06) :805-821

[2] Patterns of brain activation in people at risk for Alzheimer's disease [J].

Bookheimer, SY ;

Strojwas, MH ;

Cohen, MS ;

Saunders, AM ;

Pericak-Vance, MA ;

Mazziotta, JC ;

Small, GW .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (07) :450-456

[3] KIBRA is a novel substrate for protein kinase Cξ [J].

Büther, K ;

Plaas, C ;

Barnekow, A ;

Kremerskothen, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 317 (03) :703-707

[4] Imaging cognition II: An empirical review of 275 PET and fMRI studies [J].

Cabeza, R ;

Nyberg, L .

JOURNAL OF COGNITIVE NEUROSCIENCE, 2000, 12 (01) :1-47

[5]

Caselli R J, 2004, Neurology, V62, P1990

[6] Population structure, differential bias and genomic control in a large-scale, case-control association study [J].

Clayton, DG ;

Walker, NM ;

Smyth, DJ ;

Pask, R ;

Cooper, JD ;

Maier, LM ;

Smink, LJ ;

Lam, AC ;

Ovington, NR ;

Stevens, HE ;

Nutland, S ;

Howson, JMM ;

Faham, M ;

Moorhead, M ;

Jones, HB ;

Falkowski, M ;

Hardenbol, P ;

Willis, TD ;

Todd, JA .

NATURE GENETICS, 2005, 37 (11) :1243-1246

[7] Applications of whole-genome high-density SNP genotyping [J].

Craig, DW ;

Stephan, DA .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2005, 5 (02) :159-170

[8] Identification of a genetic cluster influencing memory performance and hippocampal activity in humans [J].

de Quervain, DJF ;

Papassotiropoulos, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (11) :4270-4274

[9] A functional genetic variation of the 5-HT2a receptor affects human memory [J].

de Quervain, DJF ;

Henke, K ;

Aerni, A ;

Coluccia, D ;

Wollmer, MA ;

Hock, C ;

Nitsch, RM ;

Papassotiropoulos, A .

NATURE NEUROSCIENCE, 2003, 6 (11) :1141-1142

[10] Implicit associative learning engages the hippocampus and interacts with explicit associative learning [J].

Degonda, N ;

Mondadori, CRA ;

Bosshardt, S ;

Schmidt, CF ;

Boesiger, P ;

Nitsch, RM ;

Hock, C ;

Henke, K .

NEURON, 2005, 46 (03) :505-520

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