Synthesis and evaluation of novel oxazoline MMP inhibitors

被引：17

作者：

Cook, GR ^{[1
]}

Manivannan, E

Underdahl, T

Lukacova, V

Zhang, YF

Balaz, S

机构：

[1] N Dakota State Univ, Ctr Protease Res, Dept Chem Biochem & Mol Biol, Fargo, ND 58105 USA

[2] N Dakota State Univ, Ctr Protease Res, Dept Pharmaceut Sci, Fargo, ND 58105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 19期

关键词：

MMP inhibitors; oxazolines; heterocycles; zinc binding;

D O I：

10.1016/j.bmcl.2004.07.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4935 / 4939

页数：5

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