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Enantioselective aldol reaction with a bromofluoroketene silyl acetal catalyzed by a chiral Lewis acid

被引：28
作者：
Iseki, K
Kuroki, Y
Kobayashi, Y
机构：
[1] MEC Laboratory, Daikin Industries, Ltd., Miyukigaoka, Tsukuba
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 41期
关键词：
D O I：
10.1016/S0040-4039(97)01717-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bromofluoroketene silyl acetal 1 was prepared in pure form. Aldol reactions of 1 with achiral aldehydes catalyzed by chiral Lewis acid 2 proceeded with high enantioselectivity to give optically active syn- and anti-alpha-bromo-alpha-fluoro-beta-hydroxy esters 3a-h, respectively (up to 99% ee). (C) 1997 Elsevier Science Ltd.
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页码：7209 / 7210
页数：2
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