From molecular to modular cell biology

被引：2495

作者：

Hartwell, LH ^{[1
]}

Hopfield, JJ

Leibler, S

Murray, AW

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08542 USA

[3] Princeton Univ, Dept Phys & Mol Biol, Princeton, NJ 08542 USA

[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

来源：

NATURE | 1999年 / 402卷 / 6761期

关键词：

D O I：

10.1038/35011540

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cellular functions, such as signal transmission, are carried out by 'modules' made up of many species of interacting molecules, Understanding how modules work has depended on combining phenomenological analysis with molecular studies. General principles that govern the structure and behaviour of modules may be discovered with help from synthetic sciences such as engineering and computer science, from stronger interactions between experiment and theory in cell biology, and from an appreciation of evolutionary constraints.

引用

页码：C47 / C52

页数：6

共 34 条

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