New eudesmane sesquiterpenes from the marine-derived fungus Penicillium thomii

被引：20

作者：

Afiyatullov, Shamil Sh. ^{[1
]}

Leshchenko, Elena V. ^{[2
]}

Sobolevskaya, Maria P. ^{[1
]}

Denisenko, Vladimir A. ^{[1
]}

Kirichuk, Natalya N. ^{[1
]}

Khudyakova, Yuliya V. ^{[1
]}

Hoai, Trinh P. T. ^{[3
]}

Dmitrenok, Pavel S. ^{[1
]}

Menchinskaya, Ekaterina S. ^{[1
]}

Pislyagin, Evgeny A. ^{[1
]}

Berdyshev, Dmitrii V. ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Far Eastern Fed Univ, Vladivostok 690950, Russia

[3] Vietnam Acad Sci & Technol, Nha Trang Inst Technol Res & Applicat, Hanoi, Vietnam

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 14卷

基金：

俄罗斯基础研究基金会;

关键词：

Penicillium thomii; Zostera marina; Sesquiterpenes; NO; ALPINIA-OXYPHYLLA; NITRIC-OXIDE; CELLS;

D O I：

10.1016/j.phytol.2015.10.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new eudesmane-type sesquiterpenes thomimarines A-D (1-4) were isolated from the marine-derived fungus Penicillium thomii. Their structures were established based on spectroscopic methods. The absolute configurations of 1-4 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Inhibitory effects of compounds 1, 2 and 4 on NO production in LPS-induced RAW 264.7 murine macrophages were evaluated. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：209 / 214

页数：6

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