New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia

被引：40

作者：

Jiang, Bei ^{[1
,2
]}

Wang, Wen-Jing ^{[1
,2
]}

Li, Man-Ping ^{[1
]}

Huang, Xiao-Jun ^{[1
,2
]}

Huang, Feng ^{[1
]}

Gao, Hao ^{[1
,2
]}

Sun, Ping-Hua ^{[1
]}

He, Ming-Fang ^{[3
]}

Jiang, Zheng-Jin ^{[1
]}

Zhang, Xiao-Qi ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Nanjing Univ Technol, Sch Pharmaceut Sci, Sinoamer Canc Ctr, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Alpinia oxyphylla; Zingiberaceae; Noreudesmane sesquiterpenoid; Microglia; Neuroprotection; NITRIC-OXIDE PRODUCTION; ABSOLUTE STEREOSTRUCTURES; FRUITS; NOOTKATONE; LACTONES; NEURONS; FRUCTUS;

D O I：

10.1016/j.bmcl.2013.04.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1-3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3879 / 3883

页数：5

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