Asymmetry in the boronic acid Mannich reaction: Diastereocontrolled addition to chiral iminium species derived from aldehydes and (S)-5-phenylmorpholin-2-one

被引：47

作者：

Harwood, LM

Currie, GS

Drew, MGB

Luke, RWA

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 16期

关键词：

D O I：

10.1039/cc9960001953

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(S)-5-Phenylmorpholin-2-one dagger and a range of aliphatic aldehydes form chiral iminium. intermediates which undergo diastereoselective Mannich reactions with 2-furylboronic acid, Single crystal X-ray analysis of methylated derivative 4 derived from. major adduct 2g confirms the stereochemical course of the reaction.

引用

页码：1953 / 1954

页数：2

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