IL-9 as a mediator of Th17-driven inflammatory disease

被引：314

作者：

Nowak, Elizabeth C. ^{[1
,2
]}

Weaver, Casey T. ^{[3
]}

Turner, Henrietta ^{[3
]}

Begum-Haque, Sakhina ^{[1
,2
]}

Becher, Burkhard ^{[4
]}

Schreiner, Bettina ^{[4
]}

Coyle, Anthony J. ^{[5
]}

Kasper, Lloyd H. ^{[1
,2
]}

Noelle, Randolph J. ^{[1
,2
]}

机构：

[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

[3] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[4] Univ Zurich Hosp, Dept Pathol, Inst Expt Immunol, CH-8057 Zurich, Switzerland

[5] Medimmune Inc, Dept Autoimmun & Inflammat, Gaithersburg, MD 20878 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 08期

基金：

美国国家卫生研究院;

关键词：

EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MAST-CELLS; T-CELLS; MURINE MODEL; TGF-BETA; RECEPTOR; DIFFERENTIATION; INTERLEUKIN-9; PROMOTES; CNS;

D O I：

10.1084/jem.20090246

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report that like other T cells cultured in the presence of transforming growth factor (TGF)beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6-producing macrophages in the central nervous system, as well as mast cell numbers in the regional lymph nodes. Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease.

引用

页码：1653 / 1660

页数：8

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