MicroRNAs: History, Biogenesis, and Their Evolving Role in Animal Development and Disease

被引：476

作者：

Bhaskaran, M. ^{[1
]}

Mohan, M. ^{[2
]}

机构：

[1] Tulane Natl Primate Res Ctr, Div Microbiol, Covington, LA 70433 USA

[2] Tulane Natl Primate Res Ctr, Div Comparat Pathol, Covington, LA 70433 USA

来源：

VETERINARY PATHOLOGY | 2014年 / 51卷 / 04期

基金：

美国国家卫生研究院;

关键词：

animal microRNA; miR; oncomiR; apoptomiR; circulating miRNA; biomarkers; TUMOR-SUPPRESSOR; CELLULAR MICRORNAS; VIRUS-REPLICATION; RHEUMATOID-ARTHRITIS; GENE-EXPRESSION; DOWN-REGULATION; NONCODING RNAS; MESSENGER-RNAS; NUCLEAR EXPORT; ENZYME DICER;

D O I：

10.1177/0300985813502820

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries in small RNA biology have redefined the biological landscape by significantly altering the longstanding dogmas that defined gene regulation. These small RNAs play a significant role in modulation of an array of physiological and pathological processes ranging from embryonic development to neoplastic progression. Unique miRNA signatures of various inherited, metabolic, infectious, and neoplastic diseases have added a new dimension to the studies that look at their pathogenesis and highlight their potential to be reliable biomarkers. Also, altering miRNA functionality and the development of novel in vivo delivery systems to achieve targeted modulation of specific miRNA function are being actively pursued as novel approaches for therapeutic intervention in many diseases. Here we review the current body of knowledge on the role of miRNAs in development and disease and discuss future implications.

引用

页码：759 / 774

页数：16

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