Association of SWAP-70 with the B cell antigen receptor complex

被引：43

作者：

Masat, L

Caldwell, J

Armstrong, R

Khoshnevisan, H

Jessberger, R

Herndier, B

Wabl, M ^{[1
]}

Ferrick, D

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[3] Basel Inst Immunol, CH-4005 Basel, Switzerland

[4] Rigel, S San Francisco, CA 94080 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 05期

关键词：

D O I：

10.1073/pnas.040374497

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.

引用

页码：2180 / 2184

页数：5

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