Immunology - The roots of antibody diversity

被引:20
作者
Gearhart, PJ [1 ]
机构
[1] NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USA
关键词
D O I
10.1038/419029a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
When faced with foreign molecules our antibodies mutate, allowing them to bind to the intruders more strongly. In a story full of surprises, it looks as though the mechanism of mutation has finally been revealed.
引用
收藏
页码:29 / +
页数:2
相关论文
共 13 条
[1]   5′-Deoxyribose phosphate lyase activity of human DNA polymerase ι in vitro [J].
Bebenek, K ;
Tissier, A ;
Frank, EG ;
McDonald, JP ;
Prasad, R ;
Wilson, SH ;
Woodgate, R ;
Kunkel, TA .
SCIENCE, 2001, 291 (5511) :2156-2159
[2]   DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation [J].
Bross, L ;
Muramatsu, M ;
Kinoshita, K ;
Honjo, T ;
Jacobs, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) :1187-1192
[3]   Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase [J].
Di Noia, J ;
Neuberger, MS .
NATURE, 2002, 419 (6902) :43-48
[4]   Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ [J].
Diaz, M ;
Verkoczy, LK ;
Flajnik, MF ;
Klinman, NR .
JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :327-335
[5]   Altered nucleotide misinsertion fidelity associated with polι-dependent replication at the end of a DNA template [J].
Frank, EG ;
Tissier, A ;
McDonald, JP ;
Rapic-Otrin, V ;
Zeng, XM ;
Gearhart, PJ ;
Woodgate, R .
EMBO JOURNAL, 2001, 20 (11) :2914-2922
[6]   Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme [J].
Muramatsu, M ;
Kinoshita, K ;
Fagarasan, S ;
Yamada, S ;
Shinkai, Y ;
Honjo, T .
CELL, 2000, 102 (05) :553-563
[7]   The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process [J].
Papavasiliou, FN ;
Schatz, DG .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) :1193-1198
[8]   Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene [J].
Pavlov, YI ;
Rogozin, IB ;
Galkin, AP ;
Aksenova, AY ;
Hanaoka, F ;
Rada, C ;
Kunkel, TA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :9954-9959
[9]   Somatic hypermutation of immunoglobulin genes is linked to transcription initiation [J].
Peters, A ;
Storb, U .
IMMUNITY, 1996, 4 (01) :57-65
[10]   AID mutates E-coli suggesting a DNA deamination mechanism for antibody diversification [J].
Petersen-Mahrt, SK ;
Harris, RS ;
Neuberger, MS .
NATURE, 2002, 418 (6893) :99-103