A1 adenosine receptor agonists:: Medicinal chemistry and therapeutic potential

被引：29

作者：

Hutchinson, SA

Scammells, PJ

机构：

[1] Monash Univ, Victorian Coll Pharm, Dept Med Chem, Parkville, Vic 3052, Australia

[2] CSIRO, Div Text & Fibre Technol, Belmont, Vic 3216, Australia

来源：

CURRENT PHARMACEUTICAL DESIGN | 2004年 / 10卷 / 17期

关键词：

D O I：

10.2174/1381612043384204

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adenosine receptors are widely distributed in the body and modulate numerous physiological processes. Four receptor Subtypes (termed A(1), A(2), A(2B) and A(3)) have been identified based on their pharmacological profile and cloning. Activation of the A(1) adenosine receptors produces a number of effects including a reduction in heart rate and atrial contractility, the attenuation of the stimulatory actions of catecholamines on the heart as well as a reduction of lipolysis in adipose tissue. As a result, A(1)AR agonists have been targeted as anti-arrhythmic and cardioprotective agents. This review discusses the synthesis, structure-activity relationships and therapeutic potential of A(1)AR agonists.

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页码：2021 / 2039

页数：19

相关论文

共 139 条

[41] Negative chronotropic effect of CVT-510 in anesthetized and awake rats [J].

Gao, ZH ;

Rosete, J ;

Kohler, G ;

Huang, BL ;

Blackburn, B ;

Belardinelli, L .

DRUG DEVELOPMENT RESEARCH, 2001, 52 (1-2) :424-430

[42]

Geiger JD, 1991, ADENOSINE NERVOUS SY, P1, DOI [10.1016/ B978-0-12-672640-4.50007-8, DOI 10.1016/B978-0-12-672640-4.50007-8]

[43] FUNCTIONAL-CHARACTERIZATION OF 3 ADENOSINE RECEPTOR TYPES [J].

GURDEN, MF ;

COATES, J ;

ELLIS, F ;

EVANS, B ;

FOSTER, M ;

HORNBY, E ;

KENNEDY, I ;

MARTIN, DP ;

STRONG, P ;

VARDEY, CJ ;

WHEELDON, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 109 (03) :693-698

[44] An improved approach to the synthesis of adenosine-5'-N-ethyluronamides of interest as adenosine receptor agonists [J].

Ha, SB ;

Nair, V .

TETRAHEDRON LETTERS, 1996, 37 (10) :1567-1570

[45] MODEL FOR THE STRUCTURE OF BACTERIORHODOPSIN BASED ON HIGH-RESOLUTION ELECTRON CRYOMICROSCOPY [J].

HENDERSON, R ;

BALDWIN, JM ;

CESKA, TA ;

ZEMLIN, F ;

BECKMANN, E ;

DOWNING, KH .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 213 (04) :899-929

[46] Applications of adenosine receptor ligands in medical imaging by positron emission tomography [J].

Holschbach, MH ;

Olsson, RA .

CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (26) :2345-2352

[47] New 2,N6-disubstituted adenosines:: Potent and selective A1 adenosine receptor agonists [J].

Hutchinson, SA ;

Baker, SP ;

Scammells, PJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (04) :1115-1122

[48] Adenosine receptor ligands with oxygenated N6-substituents [J].

Hutchinson, SA ;

Baker, SP ;

Scammells, PJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (07) :933-936

[49] 2-(ARYLALKYLAMINO)ADENOSIN-5'-URONAMIDES - A NEW CLASS OF HIGHLY SELECTIVE ADENOSINE-A2 RECEPTOR LIGANDS [J].

HUTCHISON, AJ ;

WILLIAMS, M ;

DEJESUS, R ;

YOKOYAMA, R ;

OEI, HH ;

GHAI, GR ;

WEBB, RL ;

ZOGANAS, HC ;

STONE, GA ;

JARVIS, MF .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) :1919-1924

[50]

Ijzerman A. P., 1997, P129

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