Quantum Dots - Characterization, Preparation and Usage in Biological Systems

被引:224
作者
Drbohlavova, Jana [1 ]
Adam, Vojtech [2 ]
Kizek, Rene [2 ]
Hubalek, Jaromir [1 ]
机构
[1] Brno Univ Technol, Fac Elect Engn & Commun, Dept Microelect, Brno 60200, Czech Republic
[2] Mendel Univ Brno, Fac Agron, Dept Chem & Biochem, Brno 61300, Czech Republic
关键词
Quantum dots; biosensing; biolabeling; template methods; TiO2; CORE/SHELL NANOCRYSTALS; LIVING CELLS; LIVE CELL; NANOPARTICLES; LUMINESCENT; TIO2; FLUORESCENT; SIZE; PHOTOLUMINESCENCE; BIOCONJUGATION;
D O I
10.3390/ijms10020656
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The use of fluorescent nanoparticles as probes for bioanalytical applications is a highly promising technique because fluorescence-based techniques are very sensitive. Quantum dots (QDs) seem to show the greatest promise as labels for tagging and imaging in biological systems owing to their impressive photostability, which allow long-term observations of biomolecules. The usage of QDs in practical applications has started only recently, therefore, the research on QDs is extremely important in order to provide safe and effective biosensing materials for medicine. This review reports on the recent methods for the preparation of quantum dots, their physical and chemical properties, surface modification as well as on some interesting examples of their experimental use.
引用
收藏
页码:656 / 673
页数:18
相关论文
共 100 条
[31]   A double templated electrodeposition method for the fabrication of arrays of metal nanodots [J].
Ghanem, MA ;
Bartlett, PN ;
de Groot, P ;
Zhukov, A .
ELECTROCHEMISTRY COMMUNICATIONS, 2004, 6 (05) :447-453
[32]   Luminescent quantum dots in immunoassays [J].
Goldman, ER ;
Medintz, IL ;
Mattoussi, H .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2006, 384 (03) :560-563
[33]   Determination of size and composition of optically active CdZnSe/ZnBeSe quantum dots [J].
Gu, Y ;
Kuskovsky, IL ;
Fung, J ;
Robinson, R ;
Herman, IP ;
Neumark, GF ;
Zhou, X ;
Guo, SP ;
Tamargo, MC .
APPLIED PHYSICS LETTERS, 2003, 83 (18) :3779-3781
[34]   One-pot synthesis of highly luminescent CdTe/CdS core/shell nanocrystals in aqueous phase [J].
Gu, Zhenyu ;
Zou, Lei ;
Fang, Zheng ;
Zhu, Weihong ;
Zhong, Xinhua .
NANOTECHNOLOGY, 2008, 19 (13)
[35]   Size determination of InAs quantum dots using magneto-tunnelling experiments [J].
Hapke-Wurst, I ;
Zeitler, U ;
Schumacher, HW ;
Haug, RJ ;
Pierz, K ;
Ahlers, FJ .
SEMICONDUCTOR SCIENCE AND TECHNOLOGY, 1999, 14 (11) :L41-L43
[36]   A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors [J].
Hardman, R .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 (02) :165-172
[37]  
HAZDRA P, 2006, OPTICAL CHARACTERISA, P1070
[38]   Properties and applications of quantum dot heterostructures grown by molecular beam epitaxy [J].
Henini, M. .
NANOSCALE RESEARCH LETTERS, 2006, 1 (01) :32-45
[39]   Linearly polarized emission from colloidal semiconductor quantum rods [J].
Hu, JT ;
Li, LS ;
Yang, WD ;
Manna, L ;
Wang, LW ;
Alivisatos, AP .
SCIENCE, 2001, 292 (5524) :2060-2063
[40]   Preparation and application of L-cysteine-modified CdSe/CdS core/shell nanocrystals as a novel fluorescence probe for detection of nucleic acid [J].
Huang, Fenghua ;
Chen, Guonan .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2008, 70 (02) :318-323