Integrin activation takes shape

被引：245

作者：

Liddington, RC

Ginsberg, MH

机构：

[1] Burnham Inst, Program Cell Adhes, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Cell Biol, Div Vasc Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 158卷 / 05期

关键词：

integrin; adhesion; affinity regulation; cytoplasmic domain; transmembrane domain;

D O I：

10.1083/jcb.200206011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here we summarize recent findings on the regulation of integrin affinity for ligand (activation), one mechanism by which cells modulate integrin function. The focus is on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity regulation, and potential mechanisms by which activation signals are propagated from integrin cytoplasmic domains to the extracellular ligand-binding domain.

引用

收藏

页码：833 / 839

页数：7

相关论文

共 49 条

[1] Does the integrin αA domain act as a ligand for its βA domain? [J].

Alonso, JL ;

Essafi, M ;

Xiong, JP ;

Stehle, T ;

Arnaout, MA .

CURRENT BIOLOGY, 2002, 12 (10) :R340-R342

[2] Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits [J].

Armulik, A ;

Nilsson, I ;

von Heijne, G ;

Johansson, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) :37030-37034

[3] BETA(2) (CD18) MUTATIONS ABOLISH LIGAND RECOGNITION BY I-DOMAIN INTEGRINS LFA-1 (ALPHA(L)BETA(2), CD11A/CD18) AND MAC-1 (ALPHA(M)BETA(2), CD11B/CD18) [J].

BAJT, ML ;

GOODMAN, T ;

MCGUIRE, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) :94-98

[4] A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro [J].

Baker, EK ;

Tozer, EC ;

Pfaff, M ;

Shattil, SJ ;

Loftus, JC ;

Ginsberg, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1973-1978

[5]

BEER JH, 1992, BLOOD, V79, P117

[6] Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation [J].

Beglova, N ;

Blacklow, SC ;

Takagi, J ;

Springer, TA .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (04) :282-287

[7] Structural aspects of heterotrimeric G-protein signaling [J].

Bohm, A ;

Gaudet, R ;

Sigler, PB .

CURRENT OPINION IN BIOTECHNOLOGY, 1997, 8 (04) :480-487

[8] ERM-merlin and EBP50 protein families in plasma membrane organization and function [J].

Bretscher, A ;

Chambers, D ;

Nguyen, R ;

Reczek, D .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 :113-+

[9] The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation [J].

Calderwood, DA ;

Zent, R ;

Grant, R ;

Rees, DJG ;

Hynes, RO ;

Ginsberg, MH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) :28071-28074

[10] The phosphotyrosine binding-like domain of talin activates Integrins [J].

Calderwood, DA ;

Yan, BX ;

de Pereda, JM ;

Alvarez, BG ;

Fujioka, Y ;

Liddington, RC ;

Ginsberg, MH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21749-21758

← 1 2 3 4 5 →