Oncogenic γ-herpesviruses:: Comparison of viral proteins involved in tumorigenesis

被引：103

作者：

Damania, B ^{[1
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 08期

关键词：

D O I：

10.1038/nrmicro958

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpesviruses are present in most species throughout the animal kingdom and are classified into three subfamilies, alpha, beta and gamma, on the basis of their biological properties and genome sequences. A striking feature that is shared by many of the gamma-herpesviruses is their ability to induce neoplastic disease in the host. This review focuses on three gamma-herpesviruses: Epstein - Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and herpesvirus saimiri (HVS), and discusses the diverse array of EBV, KSHV and HVS viral genes that are involved in transformation, cell signalling, episomal maintenance and cell proliferation.

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页码：656 / 668

页数：13

相关论文

共 163 条

[1] Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [J].

Arvanitakis, L ;

GerasRaaka, E ;

Varma, A ;

Gershengorn, MC ;

Cesarman, E .

NATURE, 1997, 385 (6614) :347-350

[2] Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR [J].

Bais, C ;

Van Geelen, A ;

Eroles, P ;

Mutlu, A ;

Chiozzini, C ;

Dias, S ;

Silverstein, RL ;

Rafii, S ;

Mesri, EA .

CANCER CELL, 2003, 3 (02) :131-143

[3] G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [J].

Bais, C ;

Santomasso, B ;

Coso, O ;

Arvanitakis, L ;

Raaka, EG ;

Gutkind, JS ;

Asch, AS ;

Cesarman, E ;

Gerhengorn, MC ;

Mesri, EA .

NATURE, 1998, 391 (6662) :86-89

[4] Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen [J].

Ballestas, ME ;

Chatis, PA ;

Kaye, KM .

SCIENCE, 1999, 284 (5414) :641-644

[5] Interleukin-10 abrogates the inhibition of Epstein-Barr virus-induced B-cell transformation by memory T-cell responses [J].

Bejarano, MT ;

Masucci, MG .

BLOOD, 1998, 92 (11) :4256-4262

[6] THE PRODUCT OF THE HERPESVIRUS-SAIMIRI OPEN READING FRAME-1 (TIP) INTERACTS WITH T-CELL-SPECIFIC KINASE P56(LCK) IN TRANSFORMED-CELLS [J].

BIESINGER, B ;

TSYGANKOV, AY ;

FICKENSCHER, H ;

EMMRICH, F ;

FLECKENSTEIN, B ;

BOLEN, JB ;

BROKER, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) :4729-4734

[7] Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines [J].

Boshoff, C ;

Endo, Y ;

Collins, PD ;

Takeuchi, Y ;

Reeves, JD ;

Schweickart, VL ;

Siani, MA ;

Sasaki, T ;

Williams, TJ ;

Gray, PW ;

Moore, PS ;

Chang, Y ;

Weiss, RA .

SCIENCE, 1997, 278 (5336) :290-294

[8] Activation of mitogen-activated protein kinase and NF-κB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein [J].

Brinkmann, MM ;

Glenn, M ;

Rainbow, L ;

Kieser, A ;

Henke-Gendo, C ;

Schulz, TF .

JOURNAL OF VIROLOGY, 2003, 77 (17) :9346-9358

[9] CONSISTENT TRANSCRIPTION OF THE EPSTEIN-BARR-VIRUS LMP2 GENE IN NASOPHARYNGEAL CARCINOMA [J].

BUSSON, P ;

MCCOY, R ;

SADLER, R ;

GILLIGAN, K ;

TURSZ, T ;

RAABTRAUB, N .

JOURNAL OF VIROLOGY, 1992, 66 (05) :3257-3262

[10] The herpesvirus saimiri ORF73 gene product interacts with host-cell mitotic chromosomes and self-associates via its C terminus [J].

Calderwood, MA ;

Hall, KT ;

Matthews, DA ;

Whitehouse, A .

JOURNAL OF GENERAL VIROLOGY, 2004, 85 :147-153

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