Double C-H activation during functionalization of phenyl(methyl)ketene on iridium(I) using alkynes. synthesis of 1,4-dien-3-ones

被引：37

作者：

Grotjahn, DB

Hoerter, JM

Hubbard, JL

机构：

[1] San Diego State Univ, Dept Chem, San Diego, CA 92182 USA

[2] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 29期

关键词：

D O I：

10.1021/ja048489+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Under the influence of an Ir(I) metal fragment, the methyl group of phenyl(methyl)ketene undergoes two C-H activations in reacting with internal alkynes, giving metallacycles 3 in 86-94% yield. Treatment of 3 with CO liberates 1,4-dien-3-ones 5 in 81-93% yield, along with CO complex 4. A possible mechanism for the very selective double C-H activation-alkyne coupling is discussed. Copyright © 2004 American Chemical Society.

引用

页码：8866 / 8867

页数：2

共 31 条

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