Quantification of a CH-π Interaction Responsible for Chiral Discrimination and Evaluation of Its Contribution to Enantioselectivity

被引：52

作者：

Carrillo, Romen ^{[2
]}

Lopez-Rodriguez, Matias ^{[2
]}

Martin, Victor S. ^{[2
]}

Martin, Tomas ^{[1
,2
]}

机构：

[1] CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Spain

[2] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, E-38206 Tenerife, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 42期

关键词：

chiral discrimination; CH-pi interactions; molecular recognition; noncovalent interactions; receptors; CARBOHYDRATE-AROMATIC INTERACTIONS; CH/PI HYDROGEN-BONDS; MOLECULAR RECOGNITION; SYNTHETIC LECTIN; PROTEIN; COMPLEXATION; MODEL; DNA; STABILITY; PHENYL;

D O I：

10.1002/anie.200903281

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Good things come in small interactions: The high chiral discrimination displayed by a new receptor with ammonium salts of aromatic a-amino acid methyl esters is mainly the result of one of the weakest noncovalent interactions, the CH-π interaction (see picture). The interaction has been identified and quantified, and its contribution to the chiral recognition process has been evaluated. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7803 / 7808

页数：6

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