Drosophila lifespan enhancement by exogenous bacteria

被引：238

作者：

Brummel, T

Ching, A

Seroude, L

Simon, AF

Benzer, S ^{[1
]}

机构：

[1] CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA

[2] Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada

[3] Univ Calif Los Angeles, Inst Brain Res, Los Angeles, CA 90095 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 35期

关键词：

longevity; aging; axenic flies; antibiotics;

D O I：

10.1073/pnas.0405207101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifespan. Certain long-lived mutants react in different ways, indicating an interplay between bacteria and longevity-enhancing genes.

引用

收藏

页码：12974 / 12979

页数：6

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