Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography

被引：262

作者：

Faber, DJ

van der Meer, FJ

Aalders, MCG

van Leeuwen, TG

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Laser, NL-1100 DE Amsterdam, Netherlands

[2] Univ Twente, Biomed Technol Inst, NL-7500 AE Enschede, Netherlands

来源：

OPTICS EXPRESS | 2004年 / 12卷 / 19期

关键词：

D O I：

10.1364/OPEX.12.004353

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

From calibrated, weakly scattering tissue phantoms (2-6 mm(-1)), we extract the attenuation coefficient with an accuracy of 0.8 mm(-1) from OCT data in the clinically relevant 'fixed focus' geometry. The data are analyzed using a single scattering model and a recently developed description of the confocal point spread function (PSF). We verify the validity of the single scattering model by a quantitative comparison with a multiple scattering model, and validate the use of the PSF on the calibrated samples. Implementation of this model for existing OCT systems will be straightforward. Localized quantitative measurement of the attenuation coefficient of different tissues can significantly improve the clinical value of OCT. (C) 2004 Optical Society of America.

引用

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页码：4353 / 4365

页数：13

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