Mixtures of chiral monodentate phosphites, phosphonites and phosphines as ligands in Rh-catalyzed hydrogenation of N-acyl enamines:: extension of the combinatorial approach

被引：74

作者：

Reetz, MT ^{[1
]}

Mehler, G ^{[1
]}

Meiswinkel, A ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 14期

关键词：

D O I：

10.1016/j.tetasy.2004.04.038

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Mixtures of BINOL-derived monodentate phosphites and phosphonites have been reacted with Rh-salts to form three (pre)catalysts, which are in equilibrium; two homo-combinations (MLLa)-L-a and (MLLb)-L-b as well as the hetero-combination (MLLb)-L-a. In these cases in which the latter is more active and more enantioselective than the former, enhanced asymmetric induction results in appropriate transition metal catalyzed reactions. This principle has been extended to include mixtures of BINOL-derived monodentate phosphites, phosphonites and phosphines as ligands in the asymmetric Rh-catalyzed hydrogenation of N-acyl enamines leading to ee values of >97%. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2165 / 2167

页数：3

共 37 条

[31] Enantioselective Rh-catalyzed hydrogenation of vinyl carboxylates with monodentate phosphite ligands [J].

Reetz, MT ;

Goossen, LJ ;

Meiswinkel, A ;

Paetzold, J ;

Jensen, JF .

ORGANIC LETTERS, 2003, 5 (17) :3099-3101

[32] Enantioselective hydrogenation of enamides catalyzed by chiral rhodium-monodentate phosphite complexes [J].

Reetz, MT ;

Mehler, G ;

Meiswinkel, A ;

Sell, T .

TETRAHEDRON LETTERS, 2002, 43 (44) :7941-7943

[33]

Reetz MT, 2000, ANGEW CHEM INT EDIT, V39, P3889, DOI 10.1002/1521-3773(20001103)39:21<3889::AID-ANIE3889>3.0.CO

[34]

2-T

[35]

REETZ MT, 2001, Patent No. 0194278

[36]

REETZ MT, 2002, Patent No. 10247633

[37]

VERIZHNIKOV LV, 1982, J GEN CHEM USSR, V52, P615

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