Glutathione-capped CdTe quantum dots for the sensitive detection of glucose

被引：102

作者：

Yuan, Jipei ^{[1
]}

Guo, Weiwei ^{[1
]}

Yin, Jianyuan ^{[2
]}

Wang, Erkang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Grad Sch, Changchun 130022, Jilin, Peoples R China

[2] Jilin Univ, Coll Pharm, Dept Tradit Chinese Med Chem, Changchun 130021, Jilin, Peoples R China

来源：

TALANTA | 2009年 / 77卷 / 05期

关键词：

Quantum dots; H2O2-sensitive; Glucose; Detection; ONE-POT SYNTHESIS; SEMICONDUCTOR CLUSTERS; OPTICAL-DETECTION; ION PROBES; LUMINESCENT; NANOCRYSTALS; CDSE; BIOSENSOR; OXIDASE; CHEMILUMINESCENCE;

D O I：

10.1016/j.talanta.2008.10.032

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and sensitive assay system for glucose based on the glutathione (GSH)-capped CdTe quantum dots (QDs) was developed. GSH-capped CdTe QDs exhibit higher sensitivity to H2O2 produced from the glucose oxidase catalyzed oxidation Of glucose, and are also more biocompatible than other thiols-capped QDs. Based on the quenching of H2O2 on GSH-capped QDs, glucose can be detected. The detection conditions containing reaction time, the concentration of glucose oxidase and the sizes of QDs were optimized and the detection limits for glucose was determined to be 0.1 mu M; two detection ranges of glucose from 1.0 mu M to 0.5 mM and from 1.0 mM to 20 mM, respectively Were obtained. The detection limit was almost a 1000 times lower than other QDs-based optical glucose sensing systems. The developed glucose detection system was simple and facile with no need of complicated enzyme immobilization and modification of QDs. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1858 / 1863

页数：6

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