Activation of glucokinase gene expression by hepatic nuclear factor 4α in primary hepatocytes

被引:36
作者
Roth, U [1 ]
Jungermann, K [1 ]
Kietzmann, T [1 ]
机构
[1] Univ Gottingen, Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany
关键词
glycolysis; hypoxia; insulin; maturity-onset diabetes of the young; metabolic zonation; nuclear receptor;
D O I
10.1042/BJ20020340
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO(2) enhanced HNF-4 levels and binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression.
引用
收藏
页码:223 / 228
页数:6
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