Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues

被引：29

作者：

Zhu, Shilei

Zhang, Yichun

Li, Ming

Yu, Jia

Zhang, Lihong

Li, Yingxia

Yu, Biao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Ocean Univ China, Minist Educ China, Marine Drug & Food Inst, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 21期

基金：

中国国家自然科学基金;

关键词：

dioscin derivatives; amide; synthesis; cytotoxicity;

D O I：

10.1016/j.bmcl.2006.08.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two series of dioscin derivatives (4a-o and 5a-o) with selected modifications at the 6' and 4"' positions of the chacotriosyl residue, respectively, were synthesized. All the 6'-N-acyl-dioscin derivatives did not show considerable inhibitory activities at 10 mu M, while most of the 4"'-O-(2-N-acyl)ethyl-dioscin derivatives behaved as potent as dioscin, against the growth of tumor cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5629 / 5632

页数：4

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