Highly effective chiral ortho-substituted BINAPO ligands (o-BINAPO):: Applications in Ru-catalyzed asymmetric hydrogenations of β-aryl-substituted β-(acylamino)acrylates and β-keto esters

被引：199

作者：

Zhou, YG ^{[1
]}

Tang, WJ ^{[1
]}

Wang, WB ^{[1
]}

Li, WG ^{[1
]}

Zhang, XM ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, Davey Lab 152, University Pk, PA 16802 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 18期

关键词：

D O I：

10.1021/ja020121u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel family of chiral ortho-substituted BINAPO ligands (o-BINAPO) were synthesized from BINOL, and their Ru complexes were highly efficient catalysts for asymmetric hydrogenation of β-aryl-substituted β-(acylamino)acrylates and β-aryl-substituted β-keto esters. The Ru-bisphosphinite catalysts can tolerate an E/Z mixture of β-aryl-substituted β-(acylamino)acrylates. These highly enantioselective hydrogenations provide a useful way to prepare β-aryl-substituted β-amino acids and β-hydroxyl acids. Copyright © 2002 American Chemical Society.

引用

页码：4952 / 4953

页数：2

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