Characterization of Large Mumps Outbreak among Vaccinated Palestinian Refugees
被引:24
作者:
Hindiyeh, Musa Y.
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Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, IsraelChaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Hindiyeh, Musa Y.
[1
]
Aboudy, Yair
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Aboudy, Yair
Wohoush, Mahmoud
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Wohoush, Mahmoud
Shulman, Lester M.
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机构:
Tel Aviv Univ, Sackler Sch Med, Sch Publ Hlth, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, IsraelChaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Shulman, Lester M.
[2
]
Ram, Daniela
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Ram, Daniela
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Levin, Tal
Frank, Tamar
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Frank, Tamar
Riccardo, Flavia
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Riccardo, Flavia
Khalili, Mohamad
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Khalili, Mohamad
Sawalha, Elias-Shlash
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Sawalha, Elias-Shlash
Obeidi, Maysoun
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Obeidi, Maysoun
Sabatinelli, Guido
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机构:Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Sabatinelli, Guido
Grossman, Zehava
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机构:
Tel Aviv Univ, Sackler Sch Med, Sch Publ Hlth, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, IsraelChaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Grossman, Zehava
[2
]
Mendelson, Ella
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机构:
Bar Ilan Univ, Fac Life Sci, Ramat Gan, IsraelChaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
Mendelson, Ella
[3
]
机构:
[1] Chaim Sheba Med Ctr, Cent Virol Lab, Viral Real Time PCR Diag, Minist Hlth,Publ Hlth Serv, IL-52621 Tel Hashomer, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Sch Publ Hlth, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel
[3] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel
During a large mumps virus (MuV) outbreak which occurred in the Palestinian refugee camps of the West Bank, 68.1% (2,636/3,871) of the cases were vaccinated with one dose of trivalent measles, mumps, and rubella (MMR) vaccine. Attack rates by camp ranged from less than 1 case per 1,000 people in the population to 43/1,000 (overall, 11/1,000). The outbreak lasted from December 2003 to June 2005, with two peaks, one from April to May 2004 and the other from March to April 2005. To control the outbreak, a mass MMR vaccination campaign was conducted in May 2005. Evaluation of the immune status of cases (n = 59) and healthy controls (n = 51) revealed high levels of mumps immunoglobulin G (IgG) and a low MuV-specific IgM in clinical cases indicative of a booster immune response. This suggested a secondary rather than a primary infection due to the insufficient protection conferred by the single vaccine dose included in the vaccination program. This prediction was further confirmed by the low seroprevalence (68.6%) found in the healthy control group, which was below the threshold level required for MuV herd immunity. Mumps diagnosis was established mainly by reverse transcription-PCR in clinical samples obtained within 48 h from the onset of disease. Of the parotid fluids and nasopharyngeal aspirates analyzed, 92% were positive for MuV RNA, while only 33% of the urine samples were positive. Phylogenetic analysis of the MuV SH gene identified the outbreak strain as the H genotype, which has been in circulation worldwide at least since 1989.
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Narita, M
Matsuzono, Y
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Matsuzono, Y
Takekoshi, Y
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Takekoshi, Y
Yamada, S
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Yamada, S
Itakura, O
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Itakura, O
Kubota, M
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Kubota, M
Kikuta, H
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Kikuta, H
Togashi, T
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Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
机构:
Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Polgreen, Philip M.
Bohnett, Lucas C.
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Univ Iowa, Coll Publ Hlth, Dept Biostat, Iowa City, IA 52242 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Bohnett, Lucas C.
Cavanaugh, Joseph E.
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Univ Iowa, Coll Publ Hlth, Dept Biostat, Iowa City, IA 52242 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Cavanaugh, Joseph E.
Gingerich, Stefan B.
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Univ Iowa, Univ Hyg Lab, Iowa City, IA USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Gingerich, Stefan B.
Desjardin, Lucy E.
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Univ Iowa, Univ Hyg Lab, Iowa City, IA USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Desjardin, Lucy E.
Harris, Meghan L.
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Iowa Dept Publ Hlth, Des Moines, IA 50319 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Harris, Meghan L.
Quinlisk, M. Patricia
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h-index: 0
机构:
Iowa Dept Publ Hlth, Des Moines, IA 50319 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Quinlisk, M. Patricia
Pentella, Michael A.
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h-index: 0
机构:
Univ Iowa, Univ Hyg Lab, Iowa City, IA USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Narita, M
Matsuzono, Y
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Matsuzono, Y
Takekoshi, Y
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h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Takekoshi, Y
Yamada, S
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Yamada, S
Itakura, O
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h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Itakura, O
Kubota, M
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Kubota, M
Kikuta, H
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Kikuta, H
Togashi, T
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
机构:
Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Polgreen, Philip M.
Bohnett, Lucas C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Publ Hlth, Dept Biostat, Iowa City, IA 52242 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Bohnett, Lucas C.
Cavanaugh, Joseph E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Publ Hlth, Dept Biostat, Iowa City, IA 52242 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Cavanaugh, Joseph E.
Gingerich, Stefan B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Univ Hyg Lab, Iowa City, IA USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Gingerich, Stefan B.
Desjardin, Lucy E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Univ Hyg Lab, Iowa City, IA USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Desjardin, Lucy E.
Harris, Meghan L.
论文数: 0引用数: 0
h-index: 0
机构:
Iowa Dept Publ Hlth, Des Moines, IA 50319 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Harris, Meghan L.
Quinlisk, M. Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Iowa Dept Publ Hlth, Des Moines, IA 50319 USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA
Quinlisk, M. Patricia
Pentella, Michael A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Univ Hyg Lab, Iowa City, IA USAUniv Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA