Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors

被引:61
作者
Murphy, EL
Glynn, SA
Fridey, J
Sacher, RA
Smith, JW
Wright, DJ
Newman, B
Gibble, JW
Ameti, DI
Nass, CC
Schreiber, GB
Nemo, GJ
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT EPIDEMIOL BIOSTAT,SAN FRANCISCO,CA 94143
[3] BLOOD BANK SAN BERNARDINO & RIVERSIDE COUNTIES,SAN BERNARDINO,CA
[4] WESTAT CORP,ROCKVILLE,MD
[5] NHLBI,NIH,BETHESDA,MD 20892
[6] GEORGETOWN UNIV HOSP,WASHINGTON,DC 20007
[7] OKLAHOMA BLOOD INST,OKLAHOMA CITY,OK
[8] AMER RED CROSS,BLOOD SERV,DETROIT,MI
关键词
D O I
10.1086/514143
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Disease associations of human T lymphotropic virus types I and II (HTLV-I and -II) infection were studied in 154 HIV-I-infected, 387 HTLV-II-infected, and 799 uninfected blood donors. Adjusted odds ratios (ORs) and 99% confidence intervals (CIs) were derived from logistic regression models controlling for demographics and relevant confounders. All subjects were human immunodeficiency virus type l-seronegative, HTLV-II was significantly associated with a history of pneumonia (OR, 26; 99% CI, 1.2-5.3), minor fungal infection (OR, 2.9; 99% CI, 1.2-7.1), and bladder or kidney infection (OR, 1.6; 99% CI, 1.0-2.5) within the past 5 years and with a lifetime history of tuberculosis (OR, 3.9; 99% CI, 1.3-11.6) and arthritis (OR, 1.8; 99% CI, 1.2-2.9). Lymphadenopathy (greater than or equal to 1 cm) was associated with both HTLV-I (OR, 6.6; 99% CI, 2.2-19.2) and HTLV-II (OR, 2.8; 99% CI, 1.1-7.1) infection, although no case of adult T cell leukemia/lymphoma was diagnosed. Urinary urgency and gait disturbance were associated with both viruses. This new finding of increased prevalence of a variety of infections in HTLV-II-positive donors suggests immunologic impairment.
引用
收藏
页码:1468 / 1475
页数:8
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