DNA nucleoside interaction and identification with carbon nanotubes

被引：147

作者：

Meng, Sheng

Maragakis, Paul

Papaloukas, Costas

Kaxiras, Efthimios ^{[1
]}

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[4] Univ Ioannina, Dept Biol Applicat & Technol, Ioannina 45110, Greece

来源：

NANO LETTERS | 2007年 / 7卷 / 01期

关键词：

D O I：

10.1021/nl0619103

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We investigate the interaction of individual DNA nucleosides with a carbon nanotube (CNT) in vacuum and in the presence of external gate voltage. We propose a scheme to discriminate between nucleosides on CNTs based on measurement of electronic features through a local probe such as scanning tunneling spectroscopy. We demonstrate through quantum mechanical calculations that these measurements can achieve 100% efficiency in identifying DNA bases. Our results support the practicality of ultrafast DNA sequencing using electrical measurements.

引用

收藏

页码：45 / 50

页数：6

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