Asymmetric Friedel-Crafts reaction mediated by new chiral auxiliaries derived from (1S)-(-)-beta-pinene: Enantioselective synthesis of (-)-8-norethyl,1'-normethyl etodolac

被引：23

作者：

Costa, PRR

Cabral, LM

Alencar, KG

Schmidt, LL

Vasconcellos, MLAA

机构：

[1] Nucleo de Pesq. de Produtos Naturais, Ctro. de Cie. da Saúde, Univ. Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, bloco H

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01658-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-8-Norethyl, 1'-normethyl Etodolac (-)-7 was synthesized in ee up to 95% from a Friedel-Crafts alkylation reaction between tryptophol 4 and the chiral beta-ketobutyrate 5h, followed by hydrolysis. (C) 1997 Elsevier Science Ltd.

引用

页码：7021 / 7024

页数：4

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