Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

被引:133
作者
Song, Fei [1 ]
Fux, Robert [1 ]
Provacia, Lisette B. [2 ]
Volz, Asisa [1 ]
Eickmann, Markus [3 ]
Becker, Stephan [3 ]
Osterhaus, Albert D. M. E. [2 ]
Haagmans, Bart L. [2 ]
Sutter, Gerd [1 ]
机构
[1] Univ Munich, Inst Infect Dis & Zoonoses, Munich, Germany
[2] Erasmus MC, Dept Virosci, Rotterdam, Netherlands
[3] Univ Marburg, Inst Virol, D-35032 Marburg, Germany
关键词
SARS-COV; RECEPTOR; INFECTION; CELL; DISEASE; FUSION; REGION; ENTRY; EMC;
D O I
10.1128/JVI.01672-13
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged as a causative agent of severe respiratory disease in humans. Here, we constructed recombinant modified vaccinia virus Ankara (MVA) expressing full-length MERS-CoV spike (S) protein (MVA-MERS-S). The genetic stability and growth characteristics of MVA-MERS-S make it a suitable candidate vaccine for clinical testing. Vaccinated mice produced high levels of serum antibodies neutralizing MERS-CoV. Thus, MVA-MERS-S may serve for further development of an emergency vaccine against MERS-CoV.
引用
收藏
页码:11950 / 11954
页数:5
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