Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects

被引:85
作者
Holsinger, RMD [1 ]
McLean, CA
Collins, SJ
Masters, CL
Evin, GV
机构
[1] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia
[2] Mental Hlth Res Inst, Parkville, Vic 3010, Australia
关键词
D O I
10.1002/ana.20144
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:898 / 899
页数:2
相关论文
共 5 条
[1]   Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid β-protein at the cell surface [J].
Chyung, JH ;
Selkoe, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) :51035-51043
[2]   β-secretase protein and activity are increased in the neocortex in Alzheimer disease [J].
Fukumoto, H ;
Cheung, BS ;
Hyman, BT ;
Irizarry, MC .
ARCHIVES OF NEUROLOGY, 2002, 59 (09) :1381-1389
[3]   Increased expression of the amyloid precursor β-secretase in Alzheimer's disease [J].
Holsinger, RMD ;
McLean, CA ;
Beyreuther, K ;
Masters, CL ;
Evin, G .
ANNALS OF NEUROLOGY, 2002, 51 (06) :783-786
[4]  
HUANG X, 2003, INT C ASP PROT INH K
[5]   Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease [J].
Yang, LB ;
Lindholm, K ;
Yan, RQ ;
Citron, M ;
Xia, WM ;
Yang, XL ;
Beach, T ;
Sue, L ;
Wong, P ;
Price, D ;
Li, R ;
Shen, Y .
NATURE MEDICINE, 2003, 9 (01) :3-4