Regulation of EMT by KLF4 in Gastrointestinal Cancer

被引：92

作者：

Cui, Jiujie ^{[1
,2
,4
]}

Shi, Min ^{[3
,4
]}

Quan, Ming ^{[1
,2
,4
]}

Xie, Keping ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Oncol, Peoples Hosp 1, Sch Med, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Key Lab Pancreat Dis, Peoples Hosp 1, Sch Med, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Surg, Affiliated Ruijin Hosp, Shanghai 200030, Peoples R China

[4] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

来源：

CURRENT CANCER DRUG TARGETS | 2013年 / 13卷 / 09期

基金：

美国国家卫生研究院;

关键词：

EMT; gastrointestinal cancer; KLF4; Notch; TGF-beta; Wnt; KRUPPEL-LIKE FACTOR-4; EPITHELIAL-MESENCHYMAL TRANSITION; ZINC-FINGER PROTEIN; GROWTH-FACTOR-BETA; CELL-LINE RKO; E-CADHERIN; TUMOR-SUPPRESSOR; DOWN-REGULATION; TGF-BETA; TRANSCRIPTION FACTORS;

D O I：

10.2174/15680096113136660104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Gastrointestinal (GI) cancer is characterized by its aggressiveness, but the underlying mechanism is not fully understood. Studies reveal that epithelial to mesenchymal transition (EMT), which is regulated by a series of transcription factors and signaling pathways, is strongly associated with GI cancer cell proliferation, invasion and metastasis. Importantly, EMT is a product of crosstalk between signaling pathways. Kruppel-like factor 4 (KLF4), a zinc finger-type transcription factor, is decreased or lost in most GI cancers. By transcriptionally regulating its downstream target genes, KLF4 plays important roles of GI cancer tumorigenesis, proliferation and differentiation. In this review, we focus on the mechanism of KLF4 in GI cancer EMT, and demonstrate that through crosstalk with TGF-beta, Notch, and Wnt signaling pathways, KLF4 negatively regulates EMT of GI cancers. Finally, we indicate the challenging new frontiers for KLF4 which contributes to better understanding of the mechanism of GI cancer aggressiveness.

引用

页码：986 / 995

页数：10

共 103 条

[1]

Kruppel-like factors: Three fingers in many pies [J].